Anti-transcription intermediary factor 1-gamma autoantibody ELISA development and validation
نویسندگان
چکیده
منابع مشابه
Anti-signal recognition particle autoantibody ELISA validation and clinical associations.
OBJECTIVE The aim of this study was to develop and validate a quantitative anti-signal recognition particle (SRP) autoantibody serum ELISA in patients with myositis and longitudinal association with myositis disease activity. METHODS We developed a serum ELISA using recombinant purified full-length human SRP coated on ELISA plates and a secondary antibody that bound human IgG to detect anti-S...
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A man who was aged in his 80s was hospitalized in our department because of Gottron’s sign, muscle weakness and dysphagia. He was diagnosed with dermatomyositis (DM) based on the physical symptoms, muscle enzyme elevation and the results of electromyography. Immunoprecipitation for myositis-specific antibodies revealed bands of 140/155 kDa (Picture 1), which were compatible with anti-transcript...
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INTRODUCTION Myositis specific autoantibodies are associated with unique clinical subsets and are useful biomarkers in polymyositis/dermatomyositis (PM/DM). A 120 kD protein recognized by certain patients with DM was identified and clinical features of patients with this specificity were characterized. METHODS The 120 kD protein recognized by a prototype serum was purified and identified by m...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2013
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/ket383